Socs1 CLIA Kit for Rat(Rattus norvegicus) | EIAab.comSocs1 CLIA Kit for Rat(Rattus norvegicus)

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Index > Protein center > Socs1(Gene name) > Rat

Socs1 (Gene name),

Suppressor of cytokine signaling 1 (Protein name ), SOCS1_RAT from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Socs1;

Protein name:

Suppressor of cytokine signaling 1(SOCS-1);

Alternative:

Organism:

Rat (Rattus norvegicus).

General Annotation

Sub Unit:

Interacts with multiple activated proteins of the tyrosine kinase signaling pathway including JAK family kinases, TEC, KIT, GRB2 and VAV (By similarity). Binding to JAKs is mediated through the KIR and SH2 domain to a phosphorylated tyrosine residue within the JAK JH1 domain (By similarity). Binds the SH3 domain of GRB2 via diproline determinants in the N-terminus, and the N-terminal regulatory domain of VAV (By similarity). Interacts with the Elongin BC complex (TCEB1 and TCEB2). Component of an ECS CBC(SOCS1) E3 ubiquitin-protein ligase complex which contains Elongin BC, CUL5, RBX1 and SOCS1. Interacts (via SH2 domain and SOCS box) with TRIM8 (By similarity). Interacts with CUL2. Interacts with AXL and FGFR3.

Function:

SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT3 pathway. Through binding to JAKs, inhibits their kinase activity. In vitro, also suppresses Tec protein-tyrosine activity (By similarity). Appears to be a major regulator of signaling by interleukin 6 (IL6) and leukemia inhibitory factor (LIF). Regulates interferon-gamma mediated sensory neuron survival. Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize JAK2.

Subcellular Location:

Nucleus Cytoplasmic vesicle Detected in perinuclear cytoplasmic vesicles upon interaction with FGFR3.

Protein Attributes:

Sequence length:

212

Sequence:

50:

100:

150:

200:

212:

LRDYLSSFPF | QI

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

KEGG:

rno:252971

Pfam:

PF00017

STRING:

10116.ENSRNOP00000003458

UniGene:

Rn.82754

String:

Q9QX78

Uniprot:

Q9QX78

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ELISA Kit for Rat SOCS-1

Cat.:

E1416h

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Packing:

96T

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ELISA Kit for Rat SOCS-1

Cat.:

E1416m

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96T

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ELISA Kit for Rat SOCS-1

Cat.:

E1416r

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96T

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CLIA Kit for Rat SOCS-1

Cat.:

U1416m

Price:

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MSDS:

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Packing:

96T

CLIA Kit for Rat SOCS-1

Cat.:

U1416h

Price:

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MSDS:

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Packing:

96T

CLIA Kit for Rat SOCS-1

Cat.:

U1416r

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MSDS:

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Packing:

96T

Polyclonal Antibody for Rat SOCS-1

Cat.:

P1416Rb-r

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Packing:

40ug/0.2ml

Polyclonal Antibody for Rat SOCS-1

Cat.:

P1416Rb-h

Price:

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Packing:

40ug/0.2ml

Polyclonal Antibody for Rat SOCS-1

Cat.:

P1416Rb-m

Price:

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Packing:

40ug/0.2ml

Monoclonal Antibody for Rat SOCS-1

Protein for Rat SOCS-1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

le Cam A.
Submitted (1999-06) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
strain: Sprague-Dawley.

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